Conditional dependence structure and risk spillovers between Bitcoin and fiat currencies

This paper investigates the extreme dependence and risk spillovers between Bitcoin and the currencies of the BRICS and G7 economies. We find time-varying dependence between Bitcoin and all currencies. Moreover, when analysing risk spillovers from Bitcoin to currencies, we find that Bitcoin exercises significant power over most currencies, with the South African rand and Brazilian real holding both the highest downside and upside risk before and during the COVID-19 pandemic period, respectively. When considering risk spillovers from currencies towards Bitcoin, the Japanese yen exhibits the highest downside spillovers. Importantly, we find asymmetric spillovers between extreme upward and downward movements. • We study dependencies between Bitcoin and the currencies of the BRICS and G7 economies. • We find time-varying dependence between Bitcoin and all of the fiat currencies. • Bitcoin exercises significant power over most of the considered currencies. • We find asymmetric spillovers between extreme upward and downward movements. [ FROM AUTHOR] Copyright of Emerging Markets Review is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Fit for purpose? The patents regime, the Fourth Industrial Revolution, and sustainable development

This article uses data from several publicly available databases to show that the distribution of intellectual property for frontier technologies, including those useful for sustainable development, is very highly skewed in favor of a handful of developed countries. The intellectual property rights (IPR) regime as it exists does not optimize the global flow of technology and know-how for the attainment of the sustainable development goals and is in need of updating. Some features of the Fourth Industrial Revolution imply that the current system of patents is even more in need of reform than before. COVID-19 vaccines and therapies and the vast inequality in access to these has highlighted the costs of inaction. We recommend several policy changes for the international IPR regime. Broadly, these fall into three categories: allowing greater flexibility for developing countries, reassessing the appropriateness of patents for technologies that may be considered public goods, and closing loopholes that allow for unreasonable intellectual property protections.

Internal Medicine Year in Review 2022.

A novel coronavirus infection (COVID-19) became a global epidemic just months after the first case of infection was reported in Wuhan, China in December 2019. Its spread has severely affected social systems and people's lives. In the academic world, this led to an increase in the number of papers submitted to this journal. While the number of articles submitted to the journal reached a record high in 2020, the number of articles submitted last year returned to prepandemic levels. In this article, we report on the current submission conditions, including the number of submissions and acceptance rate, as well as the citation trends of highly cited articles and those published by the journal in 2022.

Relationship between COVID-19 Pandemic-Related Life Behavior, Dispositional Mindfulness, and Psychological Health: Evidence from a Sample of Japanese Working Adults.

The present study investigated how altered daily life behavior and its self-evaluation associated with the coronavirus disease 2019 (COVID-19) pandemic relate to psychological health in Japanese working adults, and how such relationships may be moderated by dispositional mindfulness. A total of 1000 participants completed an online survey comprising questions on how they used time and self-evaluated life behavior before and during the pandemic, as well as scales on mindfulness and psychological health. The results revealed that after the pandemic, participants spent significantly more time at home and using a PC/smartphone. They were also more likely to perceive frequent exposure to COVID-19-related media reports and less likely to find their work going well. Many of these variables were significantly correlated with lower psychological health. Moreover, hierarchical multiple regression analyses revealed the moderating effects of mindfulness, such that the perceived frequency of exposure to pandemic-related media reports and poorer views that work was going well were less likely to predict lower psychological health when mindfulness was high. These findings suggest that altered daily life behavior and its self-evaluation after the pandemic are associated with deteriorated psychological health, but that mindfulness can serve as a protective factor against psychological distress among Japanese workers.

Safety and effectiveness of SARS-CoV-2 vaccination in patients with autoimmune liver diseases-a multi-center, questionnairesbased study

Purpose: The efficacy and safety of SARS-CoV-2 vaccination have been confirmed in several clinical trials. However, patients with autoimmune liver disease were not subject to clinical trials, and data on the efficacy and safety of vaccines have been not available in these population. Therefore, we retrospectively investigated the safety and effectiveness of SARS-CoV-2 vaccination by questionnaire survey targeting Japanese patients with autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC). Method(s): This is a multi-center, retrospective, cross-sectional, questionnaires-based study. Patients with AIH and PBC who are outpatients at participating facilities, 18 years of age or older, and have given consent to participate in this study are included. We distributed questionnaires asking about sex, date of birth, number and type of vaccinations, the presence and degree of adverse effects (AEs), and the presence or absence of SARS-CoV-2 infection before and after vaccination, and asked them to fill in the questionnaire. In addition, we collected the result of liver tests before and after vaccinations of participating patients from each facility. Result(s): The survey was conducted from September 2021 to May 2022. A total of 471 questionnaires were collected from 220 AIH patients (male/female = 33/187, average age 63.5 +/- 13.1 years old) and 251 PBC patients (38/213, 65.8 +/- 10.1). The number of vaccinations was 0/1/2/unknown = 4/0/210/6 for AIH and 4/2/244/1 for PBC. The median time from the second dose to the completion of the questionnaire was 156 days for AIH and 148 days for PBC. By vaccine type, 193 Pfizer, 11 Moderna, and 16 unknown in AIH, and 223/12/16 in PBC. As for AEs, pain and swelling at the injection site were the most common in both AIH and PBC (75% in the first and 64% in the second in AIH, 64%/61% in PBC), followed by general malaise (19%/21% in AIH, 19%/31% in PBC), and myalgia (16%/ 19% in AIH, 19%/14% in PBC). Fever above 38.5 degreeC was observed in 11%/11% of AIH and 11%/24% of PBC, indicating that more patients with PBC experiencing fever that AIH. Only 1 case of PBC had an anaphylactic reaction. By comparing liver tests before and after vaccinations, 4 (1.8%) and 16 (6.4%) patients with AIH and PBC, respectively, demonstrated elevation to 1.5 times the pre-vaccination value and exceeding the upper normal limit. No patients experienced severe deterioration of liver function. SARS-CoV-2 infection was reported in 4 cases (1.8%) in AIH and 3 cases (1.3%) in PBC. Conclusion(s): The safety and effectiveness of SARS-CoV-2 vaccination is comparable to those in the general population.

The 2020/2021 Tokyo Olympics: Does Japan get the gold medal or the wooden spoon?

The Tokyo 2020/2021 Olympics will go down in history as the 'Pandemic Games'. Postponed by a year due to Covid-19, they were eventually held despite broad public protest and amidst the Delta variant wave. Japan brought home a record haul of medals, yet Prime Minister Suga Yoshihide resigned in ignominy shortly after the Games ended. So, was Tokyo 2020/2021 a 'success' or a 'failure', and for whom? We examine the policy and politics of the Games, considering the attribution of 'success' and 'failure' to the Olympics across a range of issues, actors, and narratives. Reviewing their economic, public health, soft power, and political impact, we find that the Tokyo 2020/2021 Olympics remain deeply ambiguous. Prime Minister Abe Shinzō's vision of a proud, 'reborn' Japan showcasing itself to the world obviously did not come to pass;neither did the promise of a 'Recovery Olympics' aiding in the reconstruction of the post-3/11 Tohoku region. Conversely, the predictions of a COVID-19 catastrophe, of even an 'Olympic variant', also failed to transpire. Rather, the Olympics became a pared-down event forced through by vested interests, notably the IOC and Dentsu. The political fallout was contained by one-party dominance in Japan's democracy, where even a forced mega-event during a pandemic was insufficient to threaten the Liberal Democratic Party's stranglehold on power. © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

A Perspective on Current Flavivirus Vaccine Development: A Brief Review.

The flavivirus genus contains several clinically important pathogens that account for tremendous global suffering. Primarily transmitted by mosquitos or ticks, these viruses can cause severe and potentially fatal diseases ranging from hemorrhagic fevers to encephalitis. The extensive global burden is predominantly caused by six flaviviruses: dengue, Zika, West Nile, yellow fever, Japanese encephalitis and tick-borne encephalitis. Several vaccines have been developed, and many more are currently being tested in clinical trials. However, flavivirus vaccine development is still confronted with many shortcomings and challenges. With the use of the existing literature, we have studied these hurdles as well as the signs of progress made in flavivirus vaccinology in the context of future development strategies. Moreover, all current licensed and phase-trial flavivirus vaccines have been gathered and discussed based on their vaccine type. Furthermore, potentially relevant vaccine types without any candidates in clinical testing are explored in this review as well. Over the past decades, several modern vaccine types have expanded the field of vaccinology, potentially providing alternative solutions for flavivirus vaccines. These vaccine types offer different development strategies as opposed to traditional vaccines. The included vaccine types were live-attenuated, inactivated, subunit, VLPs, viral vector-based, epitope-based, DNA and mRNA vaccines. Each vaccine type offers different advantages, some more suitable for flaviviruses than others. Additional studies are needed to overcome the barriers currently faced by flavivirus vaccine development, but many potential solutions are currently being explored.

Impact of COVID-19 on the mental health of Japanese university students (years II-IV).

This study aimed to investigate the differences in mental health during COVID-19, specifically among second-, third-, and fourth-year Japanese university students (n = 2,157; n = 2,000; and n = 2,284; respectively). A one-way MANOVA was conducted to assess the association between year of enrollment (academic years 2020, 2021, and 2022) and each of the eight subscales of the counseling Center Assessment Psychological Symptoms-Japanese. For second-year students, depression and generalized anxiety mean scores were higher in 2021 than those in 2020 and 2022. Alcohol use mean scores got smaller each year. For third-year students, depression, generalized anxiety, social anxiety, hostility, and alcohol use were significantly higher in 2021 than those in 2020 and 2022. Among fourth-year students, means for all eight subscale categories were significantly higher in 2021 than those in 2020 and 2022. The findings found worsened mental health profiles during 2021, which recovered to approximate pre-pandemic levels in 2022. This study demonstrates that university students' mental health has been negatively impacted by the COVID-19 pandemic, an effect which is more salient among fourth-year students. Further, it offers insights into mental health trends among Japanese university students and a possible foundation for learning about changes among university students worldwide.

Immunogenicity and safety of a single booster dose of NVX-CoV2373 (TAK-019) in healthy Japanese adults who had previously received a primary series of COVID-19 mRNA vaccine: Primary analysis report of a phase 3 open-label trial.

BACKGROUND: We evaluated the immunogenicity and safety of a booster dose of NVX-CoV2373 in Japanese adults who had completed a primary series of COVID-19 mRNA vaccine 6-12 months previously. METHODS: This single-arm, open-label, phase 3 study, conducted at two Japanese centres, enrolled healthy adults ≥ 20 years old. Participants received a booster dose of NVX-CoV2373. The primary immunogenicity endpoint was non-inferiority (lower limit of the 95 % confidence interval [CI] ≥ 0.67) of the geometric mean titre (GMT) ratio of titres of serum neutralizing antibodies (nAbs) against the SARS-CoV-2 ancestral strain 14 days after booster vaccination (day 15) in this study, compared with those 14 days after the second primary NVX-CoV2373 vaccination (day 36) in the TAK-019-1501 study (NCT04712110). Primary safety endpoints included local and systemic solicited adverse events (AEs) up to day 7 and unsolicited AEs up to day 28. RESULTS: Between 15 April 2022 and 10 May 2022, 155 participants were screened and 150, stratified by age (20-64 years old [n = 135] or ≥ 65 years old [n = 15]), received an NVX-CoV2373 booster dose. The GMT ratio between titres of serum nAbs against the SARS-CoV-2 ancestral strain on day 15 in this study and those on day 36 in the TAK-019-1501 study was 1.18 (95 % CI, 0.95-1.47), meeting the non-inferiority criterion. Following vaccination, the proportion of participants who reported local and systemic solicited AEs up to day 7 was 74.0 % and 48.0 %, respectively. The most common local and systemic solicited AEs were tenderness (102 participants [68.0 %]) and malaise (39 participants [26.0 %]), respectively. Seven participants (4.7 %) reported unsolicited AEs between vaccination and day 28; all were severity grade ≤ 2. DISCUSSION: A single heterologous NVX-CoV2373 booster induced rapid and robust anti-SARS-CoV-2 immune responses, addressing waning immunity in healthy Japanese adults, and had an acceptable safety profile. CLINICALTRIALS: gov identifier: NCT05299359.

Addressing the Burden of Inquiries for English-as-a-Foreign-Language Students in a Self-Access Vocabulary Course

This pedagogical study performed a comparative analysis of student inquiry emails in a self-access English-as-a-foreign-language vocabulary course before and during the COVID-19 pandemic and aimed to devise measures to reduce the volume of inquiries. During the pandemic, the number of inquiries increased considerably because of the university-wide shift to online courses. This not only caused frustration for students but also increased the burden on teachers to respond to these inquiries. Our data indicated the need to envision different approaches to handling inquiries because the causes of the inquiries before and during the pandemic varied considerably. Based on the results of the Pareto analysis, we devised a set of measures focusing on the four causes of inquiries: (1) missing or misunderstanding teacher instructions, (2) applications and reports for retaking tests, (3) reporting problems or asking questions on the operation of information and communications technology (ICT), and (4) wrong choices of contact points.

Telework as a Means of Organizational Identity Change: Investigating Japanese Collectivist Culture in an ICT Company

Due to the COVID-19 pandemic, numerous companies have implemented telework to balance business continuity with employees' safety. However, telework was not a widespread phenomenon in Japan until recently. Why is a geographically decentralized workstyle not as widespread in Japan as in other nations? In a previous study, based on collected samples from 529 Japanese companies, we used statistical analyses and clarified that the communication style aligned with Japanese collectivism seriously hinders telework. The present study used qualitative analysis to investigate how the communication style associated with Japanese collectivist culture hinders the introduction of telework. Finally, we concluded that if a non-Western cultural company introduces telework, it should remove the negative aspects of the communication style associated with collectivist culture to bring about organizational change that leads to a new organizational identity. © 2022 IEEE Computer Society. All rights reserved.

Reshoring from China: comparing the economic statecraft of Japan and South Korea

This article examines the Japanese and South Korean governments' reshoring and diversification policies of supply chains especially away from China since the early 2010s, with particular attention to the measures taken under the 2020–21 pandemic. The article also explores how much Japanese and South Korean reshoring from China, a subset of foreign economic policy, counts as economic statecraft as a deliberate government attempt to achieve geopolitical objectives using ‘economic' means. One would expect these governments, which innovated proactive industrial policies and guided the private sector to catch up with developed economies in the 20th century, to have an easy time encouraging businesses to re-shore. While these two governments have employed various policy instruments to shift their economic dependence away from China, there is only limited success in motivating businesses to return to their homeland. This leads to an intriguing departure in our understanding of the capacity of those two Asian nations, which used to be considered prototypical ‘developmental states' where governments have significant influence over business behaviour. This research brings more nuance and complexity to prevailing state-as-unitary-actor assumption of the economic statecraft literature and advocates closer attention to domestic sources of foreign economic policy. © 2023 Informa UK Limited, trading as Taylor & Francis Group.

Cryptocurrency Returns Clustering Using Japanese Candlesticks: Towards a Programmatic Trading System

Cryptocurrency trading drove the attention of individual traders during and after the lockdown period caused by COVID-19 restrictions. Trading systems use Japanese candlesticks-derived technical indicators to decide on behalf of traders. They offer insights into the market trend and help traders to decide how to manage their cryptocurrency portfolio. Japanese candlesticks help visualize the movement of cryptocurrencies' prices over a given period. This transformation is widely used to forecast the future trend, volatility, and prices of a cryptocurrency. Most of the research on forecasting returns suggests using three classes, uptrend, downtrend, and insignificant changes. Within this paper, we applied KMeans clustering to the Japanese candlesticks over a daily period of five of the highest capitalized non-stable coins (Bitcoin, Ethereum, BNB coin, Cardano, and Solana). Results indicates that the optimal number of clusters is ranging from 5 to 6 clusters using the elbow method for all the considered cryptocurrencies. The range of obtained results suggests that we should opt for a per cryptocurrency number of classes when dealing with cryptocurrencies classification tasks rather than using the three classes mentioned above. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Validity, reliability, and correlates of the Smartphone Addiction Scale-Short Version among Japanese adults.

BACKGROUND: The short version of the smartphone addiction scale (SAS-SV) is widely used to measure problematic smartphone use (PSU). This study examined the validity and reliability of the SAS-SV among Japanese adults, as well as cross-sectional and longitudinal associations with relevant mental health traits and problems. METHODS: Datasets from a larger project on smartphone use and mental health were used to conduct two studies. Participants were adults aged over 20 years who carried a smartphone. RESULTS: Study 1 (n = 99,156) showed the acceptable internal consistency and structural validity of the SAS-SV with a bifactor model with three factors. For the test-retest reliability of the SAS-SV, the intraclass correlation coefficient (ICC) was .70, 95% CI [.69, 70], when the SAS-SV was measured seven and twelve months apart (n = 20,389). Study 2 (n = 3419) revealed that when measured concurrently, the SAS-SV was strongly positively correlated with another measure of PSU and moderately correlated with smartphone use time, problematic internet use (PIU), depression, the attentional factor of impulsiveness, and symptoms related to attention-deficit hyperactivity disorder and obsessive-compulsive disorder. When measured 12 months apart, the SAS-SV was positively strongly associated with another measure of PSU and PIU and moderately associated with depression. DISCUSSION: The structural validity of the SAS-SV appeared acceptable among Japanese adults with the bifactor model. The reliability of the SAS-SV was demonstrated in the subsequent seven- and twelve-month associations. CONCLUSION: The cross-sectional and longitudinal associations of the SAS-SV provided further evidence regarding PSU characteristics.

Japanese Diaspora and the Narratives of Migrants ：The Case of Australia and Diasporic Literature

The overseas emigration of Japanese citizens has been on the rise in the last three decades, reaching at the level of 1.34 million in 2021 (MOFA 2022). While the COVID-19 pandemic has resulted in its downturn, the number of Japanese citizens who obtained permanent residence overseas continued to increase, hitting a record high of 537,662 in 2021 (MOFA 2022). This article examines the factors behind this growing overseas emigration of Japanese citizens, particularly looking at its flows to Australia, which is now the second most popular destination for Japanese permanent residents. Based on the narratives of 62 research participants, this article will present the basic ideal types of Japanese emigrants and examine the themes that appeared prominently in their emigration decision-making, including the acquisition of global experience, work-life balance, gender inequality, aversion of disaster/environmental and long-term economic risks, and political concerns. It will also discuss the ways in which Japanese emigration and the diversifying experiences of Japanese citizens have impacted Japanese literature so far and how the growing presence of ‘global nomads' moving across multiple borders is likely to enrich the Japanese literature in the future by challenging the existing understanding of "Japaneseness” and the meaning of migration. © 2022, Global Institute for Japanese Studies, Korea University. All rights reserved.

Management of Anaphylaxis Associated with Vaccination for COVID-19 in Children.

By September 2022, approximately 2. 88 million doses of COVID-19 mRNA vaccine had been administered in Japanese children, and 9 cases of vaccine-related anaphylaxis had been reported. Of these, 2 cases were determined to be definite anaphylaxis by expert review, for an incidence rate of 0. 7 cases per million doses. This is equivalent to the incidence of anaphylaxis from adverse reactions to existing vaccines. If anaphylaxis occurs, pediatricians should administer an intramuscular injection of adrenaline, the first choice of treatment for anaphylaxis. The allergen contained in mRNA vaccines is likely to be polyethylene glycolPEG. Therefore, we must be cau-tious in our decision to vaccinate individuals with a history of allergic reactions to PEG-containing agents. However, since no clinical test has been established to confirm allergic reactions to PEG prior to vaccination, efforts are being made to identify high-risk patients by questionnaire. It is necessary for each facility to clearly state how to respond to anaphylaxis and share information among staff so that treatment can be reliably administered in the event of anaphylaxis.Copyright © 2022, Dokkyo University School of Medicine. All rights reserved.

Management of Anaphylaxis Associated with Vaccination for COVID-19 in Children.

By September 2022, approximately 2. 88 million doses of COVID-19 mRNA vaccine had been administered in Japanese children, and 9 cases of vaccine-related anaphylaxis had been reported. Of these, 2 cases were determined to be definite anaphylaxis by expert review, for an incidence rate of 0. 7 cases per million doses. This is equivalent to the incidence of anaphylaxis from adverse reactions to existing vaccines. If anaphylaxis occurs, pediatricians should administer an intramuscular injection of adrenaline, the first choice of treatment for anaphylaxis. The allergen contained in mRNA vaccines is likely to be polyethylene glycol(PEG). Therefore, we must be cau-tious in our decision to vaccinate individuals with a history of allergic reactions to PEG-containing agents. However, since no clinical test has been established to confirm allergic reactions to PEG prior to vaccination, efforts are being made to identify high-risk patients by questionnaire. It is necessary for each facility to clearly state how to respond to anaphylaxis and share information among staff so that treatment can be reliably administered in the event of anaphylaxis.Copyright © 2022, Dokkyo University School of Medicine. All rights reserved.

Management of Anaphylaxis Associated with Vaccination for COVID-19 in Children.

By September 2022, approximately 2. 88 million doses of COVID-19 mRNA vaccine had been administered in Japanese children, and 9 cases of vaccine-related anaphylaxis had been reported. Of these, 2 cases were determined to be definite anaphylaxis by expert review, for an incidence rate of 0. 7 cases per million doses. This is equivalent to the incidence of anaphylaxis from adverse reactions to existing vaccines. If anaphylaxis occurs, pediatricians should administer an intramuscular injection of adrenaline, the first choice of treatment for anaphylaxis. The allergen contained in mRNA vaccines is likely to be polyethylene glycol(PEG). Therefore, we must be cau-tious in our decision to vaccinate individuals with a history of allergic reactions to PEG-containing agents. However, since no clinical test has been established to confirm allergic reactions to PEG prior to vaccination, efforts are being made to identify high-risk patients by questionnaire. It is necessary for each facility to clearly state how to respond to anaphylaxis and share information among staff so that treatment can be reliably administered in the event of anaphylaxis.Copyright © 2022, Dokkyo University School of Medicine. All rights reserved.

'2022 – the first year of the EV era in Japan?' The COVID crisis and its impact on the Japanese automobile industry

Has the COVID pandemic just been another crisis that had hit the Japanese automobile industry over the past three decades or has it been a watershed moment with respect to the shift to electric cars (EVs)? After presenting data regarding the development of Japanese industry and the evolution of policies for ecological friendly cars, the paper argues that, given that all major automobile markets and most foreign competitors are shifting towards battery electric vehicles (BEVs), the Japanese automobile producers have no choice other than abandoning conventional combustion engines including hybrid technologies and changing their strategies as well to BEVs. They do so, not because of government carbon neutral policies or out of conviction of the ecological superiority of BEVs, but just out of pure pragmatism in order to maintain their international competitiveness regarding products and production. COVID did not trigger but accelerated these developments.